Linqi Zhang

RNAverse, a multimodal generative model, designs functional RNAs with high performance across tasks, outperforming existing methods and enabling applications in gene therapy and vaccine development.

This paper identifies a low-affinity SARS-CoV-2 antibody, P5-1C8, that neutralizes Omicron JN.1 through IgG-mediated spike aggregation rather than direct binding.

FlowDesign improves antibody CDR design using flow matching and better priors, achieving higher affinity and neutralizing potency against HIV mutants.

This study uses cryo-EM to show that the W328-6H2 antibody forms different structures with SARS and Omicron BA.1 spike proteins, revealing a supplementary neutralization mechanism beyond RBD-Fab binding.

This study identifies natural antibodies that enable Kupffer cells to capture and kill encapsulated bacteria in the liver, offering a potential therapeutic approach for septic bacterial diseases.

DeepHINT predicts HIV-1 integration sites and explains their selection using an attention-based deep learning framework, outperforming conventional methods.