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BindCraft: one-shot design of functional protein binders
Martin Pačesa, Lennart Nickel, Christian Schellhaas…·Bruno E. Correia
Hallucinating binders by backpropagating through AlphaFold2 weights gave, across 12 targets, binders in 10-100% of the designs tested per target, mostly at nanomolar affinity.
111 citations