Author

Ana Alcaraz‐Serna

Centre Hospitalier Universitaire VaudoisORCID 0000-0002-9452-6788Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:multiple species· 1

Frequent Co-Authors

Yannick D. MülleriD· 3 shared Constantinos PetrovasiD· 2 shared Laura ErmellinoiD· 2 shared Oscar Alfageme-AbelloiD· 2 shared Raphaël PorretiD· 2 shared Rebecca CecchiniD· 2 shared Spiros GeorgakisiD· 2 shared Adrie H. WestphaliD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersImmunology

Yannick D. MüllerORCID

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3 papers

Recent·Most cited

ImmunologyScience AdvancesPeer-reviewedApr 24, 2026

Targeting PD-1+ T-cells with Chimeric Antigen Receptors to reduce the HIV Reservoir

Laura Ermellino, Riddhima Banga, Spiros Georgakis…·Yannick D. Müller

This study designs PD-1-targeting CAR-T-cells to reduce the HIV reservoir by depleting specific T-cell subpopulations in HIV-infected humanized mice.

DOI 10.1126/sciadv.aeb7602

ImmunologybioRxivPreprintMar 17, 2025

Redirecting TCR specificity in regulatory T cells toward class I HLA antigens mediates tissue-specific homing

Raphaël Porret, Fanny Lebreton, Evangelos Stefanidis…·Yannick D. Müller

The paper redirects TCR specificity in regulatory T cells toward class I HLA antigens to enhance tissue-specific homing in Type 1 Diabetes.

DOI 10.1101/2025.03.17.643496

humanexperimental assay

BioinformaticsbioRxivPreprintSep 30, 2024

✦ In-depth digest

BindCraft: one-shot design of functional protein binders

Martin Pačesa, Lennart Nickel, Christian Schellhaas…·Bruno E. Correia

Hallucinating binders by backpropagating through AlphaFold2 weights gave, across 12 targets, binders in 10-100% of the designs tested per target, mostly at nanomolar affinity.

111 citations

multiple speciesprotein structure