Amr Al‐Shebel

This paper evaluates base editing strategies for treating ADTKD-UMOD by correcting pathogenic UMOD variants and inactivating mutant alleles, showing efficient correction and expression modulation in cell models.

This study shows that kidney-specific deletion of Wdr72 causes incomplete distal renal tubular acidosis by reducing V-ATPase B1 subunit localization and impairing intercalated cell function.

This study shows that TGR5 activation in cholangiocytes induces both cAMP and IP3-Ca2+ pathways, potentially compensating for CFTR loss in cystic fibrosis.