Author

Esther N. Arwert

Institute of Cancer ResearchORCID 0000-0001-7475-9704Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alan A. MelcheriD· 2 shared Mikel Portillo· 2 shared Adrian LärkerydiD· 1 shared Alex Taylor· 1 shared Amarin WongariyapakiD· 1 shared Amy BurleyiD· 1 shared Ananya ChoudhuryiD· 1 shared Anna Clare WilkinsiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

Alan A. MelcherORCID

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2 papers

Recent·Most cited

Spatially-resolved multimodal profiling identifies functionally-heterogeneous cancer-associated fibroblasts associated with poor radiotherapy outcomes in muscle-invasive bladder cancer.

Amy Burley, Katie O’Fee, Morgane Dromby, Mi Chween Chan, Barry A. Gusterson, Adrian Lärkeryd, Emma Westlund, Priya Narayanan, Chirine Sakr, Tatiany Silveira, Rose Foster, Mikel Portillo, Marc Rabionet Diaz, Tom Lund, Alan A. Melcher, , Anna Clare Wilkins

This study identifies functionally heterogeneous cancer-associated fibroblasts in muscle-invasive bladder cancer linked to poor radiotherapy outcomes.

bioRxiv · Sep 22, 2026 · PreprintCancer Biology

Intratumoural oncolytic HSV-1 reshapes the local and systemic immune landscape through CD8+ T cell reprogramming

Elizabeth S. Appleton, Anton Patrikeev, Victoria Roulstone, Mikel Portillo, Jehanne Hassan, Shane Foo, Lisa Hubbard, Joan Kyula, Isaac Dean, Ernesto López, Charleen Chan Wah Hak, Malin Pedersen, Antonio Rullan, Chanidapa Adele Tye, Mark Allen, , Alan A. Melcher

This paper shows that intratumoural oncolytic HSV-1 reprograms systemic immunity by inducing specific CD8 T cell populations that correlate with clinical response to immunotherapy.

bioRxiv · May 29, 2026 · PreprintCancer Biology