Key residue Unlocks Dual PIP2-Dependent and Independent Gating in G Protein-Gated Inwardly Rectifying Potassium Channels
Ha Nguyen, Jonathan W. Mount, Keino Hutchinson…·Paul A. Slesinger
The paper identifies R92 as a key residue in GIRK2 channels that modulates both PIP2-dependent and independent gating mechanisms through experimental and structural analyses.