Yuan Guan

This study shows Vorinostat reduces ongoing liver fibrosis and preserves metabolic functions by altering mesenchymal cell differentiation in a human iPSC-derived model.

This study uses an AI co-scientist to identify and validate anti-fibrotic drugs in human hepatic organoids, finding that epigenomic modifiers play a key role in liver fibrosis.

The paper demonstrates that micropatterned human pluripotent stem cells can model early human cardiac vascularization in vitro, resembling a 6.5 post-conception week heart and revealing conserved vascular development programs.

This study identifies Nav1 as a gene regulating learning, memory, and responses to addictive drugs through synaptic balance changes in the cortex and hippocampus.

The paper applies haplotype-based computational genetic mapping to large-scale mouse phenotypic datasets to identify genetic factors affecting biomedical traits.