Huaxiao Yang

A Generative AI Framework to Predict Cardiomyocyte Contraction Function from Single Static Images.

This paper introduces a generative AI framework that predicts cardiomyocyte contraction from static images, achieving high accuracy and revealing structure-function relationships.

Size-Modulated Mesoderm-Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

This study uses micropatterned cardioids to investigate mesoderm-endoderm interactions in heart development, finding that pattern size affects cavity formation and signaling.

A Deep Learning-Based Scoring Framework for Large-Scale Multi-Donor Cardiotoxicity Screening

This paper develops a deep learning framework to screen for cardiotoxicity using hiPSC-derived cardiomyocytes, identifying compounds with high toxicity scores and inter-donor variability.

Micropatterned Organoids Enable Modeling of the Earliest Stages of Human Cardiac Vascularization

The paper demonstrates that micropatterned human pluripotent stem cells can model early human cardiac vascularization in vitro, resembling a 6.5 post-conception week heart and revealing conserved vascular development programs.

Membrane Curvature Promotes ER-PM Contact Formation via Junctophilin-EHD Interactions

This study shows PM curvature promotes ER-PM contact formation in cardiomyocytes via junctophilin-EHD interactions.