Zhuanfen Cheng

Absence of MBP 3' UTR in Mice Disrupts mRNA Transport, Myelination, and Motor Learning

A Tandem Repeat Atlas for the Genome of Inbred Mouse Strains: A Genetic Variation Resource

The paper creates a tandem repeat atlas for 39 inbred mouse strains using long-read sequencing, showing TRs are abundant but differ from human TRs in expansion and transposable element association.

AI-assisted Drug Re-purposing for Human Liver Fibrosis

This study uses an AI co-scientist to identify and validate anti-fibrotic drugs in human hepatic organoids, finding that epigenomic modifiers play a key role in liver fibrosis.

A Murine Database of Structural Variants Enables the Genetic Architecture of a Spontaneous Murine Lymphoma to be Characterized

The paper creates a database of structural variants in 40 inbred mouse strains and identifies an SV linked to lymphoma susceptibility in SJL mice.

Genetic Discovery Enabled by A Large Language Model

This study uses a large language model to analyze gene-phenotype relationships in mouse genetic models, identifying causative genetic factors and generating novel hypotheses for spontaneous hearing loss.

Neuron Navigator 1 Regulates Learning, Memory, and the Response to Multiple Potentially Addictive Drugs

This study identifies Nav1 as a gene regulating learning, memory, and responses to addictive drugs through synaptic balance changes in the cortex and hippocampus.

Analysis of Structural Variation Among Inbred Mouse Strains Identifies Genetic Factors for Autism-Related Traits

The paper analyzes structural variation in inbred mouse strains to identify genetic factors associated with autism-related traits.

Transcript fusion between CDKN1A and RAB44 caused by exon skipping like mechanism due to disruption of a splice site

The paper identifies a recurrent tumor-specific transcript fusion between CDKN1A and RAB44 caused by splice-site mutations and shows its correlation with TP53 inactivation and CDK activation.