Synthetic BiologyChemical SciencePeer-reviewed
Triggering the expression of a silent gene cluster from genetically intractable bacteria results in scleric acid discovery
Fabrizio Alberti, Daniel J. Leng, Ina Wilkening…·Christophe Corre
This study uses CRISPR/Cas9 to activate a silent gene cluster in Streptomyces sclerotialus, leading to the discovery of scleric acid and its biosynthetic pathway.
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