Fabrizio Alberti

This study characterizes SidG, a GNAT enzyme in Aspergillus fumigatus, revealing its iterative acetylation mechanism for siderophore biosynthesis.

This paper develops an esterase-mediated strategy to generate unstable substrates for EpnF, revealing its broad substrate tolerance and catalytic mechanism for epoxyketone synthesis.

Random forest predictors PARAS and PARASECT, trained on 3,653 curated adenylation domains, outperform earlier NRPS substrate predictors and correctly assigned L-Trp to an unusual tryptopeptin synthetase domain.

This study identifies the origin of the quinone ring in pleurotin and characterizes a biosynthetic intermediate using genome sequencing and heterologous expression.

This study uses long-read sequencing and genome assembly to identify terpene synthases and biosynthetic gene clusters in Aspergillus wentii, revealing potential pathways for bioactive molecule production.

This study uses CRISPR/Cas9 to activate a silent gene cluster in Streptomyces sclerotialus, leading to the discovery of scleric acid and its biosynthetic pathway.