Mehdi Mirzaei

The paper uses iPSC-derived RPE cells to compare molecular differences between AMD with and without reticular pseudodrusen, identifying distinct pathways and genetic influences.

The paper identifies sex-specific molecular and pathological differences in the retina-brain axis of Alzheimer's disease, linking estrogen receptor imbalance to female vulnerability.

The paper identifies UCHL1 dysregulation and synaptic loss in the retina as markers of Alzheimer's disease severity using integrated multi-omics analysis.

The paper identifies Chlamydia pneumoniae infection and NLRP3 inflammasome activation in Alzheimer's disease retinas, linking them to disease progression and cognitive impairment.

This paper demonstrates that AAV-mediated gene therapy restores retinal function and KCNV2 expression in a mouse model of KCNV2 retinopathy and human retinal organoids.

This study shows that inhibiting H3K9me3 with ETP69 reduces AD pathology and improves cognition by modulating neuroinflammation and inducing Vgf.

This study compares protein cargo differences in mesenchymal stem cell-derived extracellular vesicles isolated by three methods, finding method-specific impacts on proteome composition and biological function.

This study identifies a transient protein folding response in early TDP-43 disease that reduces aggregation, with DNAJB5 as a protective factor, and shows proteomic similarities between mouse and human TDP-43 proteinopathies.

This study identifies genetic and molecular differences in RPE cells from geographic atrophy patients compared to controls using transcriptomic and proteomic analyses.

This study compares proteomic changes in a rat glaucoma model with human glaucoma, identifying shared and distinct molecular features related to oxidative stress, mitochondrial dysfunction, and immune pathways.