Xiaochun Long

This study identifies MEIS1 as an activator of myocardin and vascular smooth muscle cell differentiation, showing its role in promoting the quiescent, differentiated state.

This study shows that loss of Leiomodin1 in vascular smooth muscle cells causes rapid coronary atherosclerosis in mice, independent of actin nucleation, and highlights Thbs1 as a target for mitigating foam cell formation.

This study uses single-cell RNA sequencing to analyze cellular and molecular changes in human veins after AVF creation, identifying inflammation and ECM deposition as key factors in AVF maturation failure.

The paper analyzes multi-omics data from human saphenous veins to identify molecular and cellular changes during neointima proliferation, highlighting sex and BMI-related differences.

This paper identifies INKILN, a human-specific lncRNA that promotes vascular smooth muscle inflammation by stabilizing MKL1 and interacting with USP10.

This paper compares two CreERT2 mice, showing Itga8-CreERT2 avoids a lethal intestinal phenotype seen with Myh11-CreERT2 when knocking out Srf.

CRISPR-LRS maps transgene integration loci and estimates copy numbers in mice, aiding breeding and phenotyping.

This paper compares CRISPR-mediated HDR and PE2 systems in mice to show PE2's higher fidelity in editing a TFBS, leading to more effective tissue-specific gene inactivation.