Sai Sangeetha Balasubramaniam

The paper shows that mitochondrial-derived compartments (MDCs) form during metabolic stress to buffer outer membrane protein load during mitochondrial adaptation.

This study identifies Yme1 as a critical protease for mitochondrial-derived compartment (MDC) formation, showing its proteolytic activity enables MDC biogenesis under stress.

This study shows that increased unsaturated fatty acids remodel the mitochondrial outer membrane by promoting the formation of mitochondrial-derived compartments and impairing TOM complex assembly.