Adam L. Hughes

Mitochondrial-derived compartments buffer outer membrane protein load during acute mitochondrial adaptation

The paper shows that mitochondrial-derived compartments (MDCs) form during metabolic stress to buffer outer membrane protein load during mitochondrial adaptation.

Vacuole pH loss triggers ESCRT-dependent plasma membrane remodeling to prevent amino acid toxicity

The paper identifies ESCRT-dependent plasma membrane remodeling as a mechanism to prevent amino acid toxicity caused by vacuole pH loss in budding yeast.

Proteolytic remodeling by Yme1 enables mitochondrial-derived compartment formation

This study identifies Yme1 as a critical protease for mitochondrial-derived compartment (MDC) formation, showing its proteolytic activity enables MDC biogenesis under stress.

Alterations in Lipid Saturation Trigger Remodeling of the Outer Mitochondrial Membrane

This study shows that increased unsaturated fatty acids remodel the mitochondrial outer membrane by promoting the formation of mitochondrial-derived compartments and impairing TOM complex assembly.

Nutrient-Responsive Formation of Mitochondrial-Derived Structures in Caenorhabditis elegans

This study identifies nutrient-responsive mitochondrial-derived structures in C. elegans muscle cells induced during refeeding, revealing a role in mitochondrial remodeling and metabolic adaptation.

Amino acids trigger MDC-dependent mitochondrial remodeling by altering mitochondrial function

The paper shows amino acids trigger MDC-dependent mitochondrial remodeling by altering mitochondrial metabolism and TCA cycle metabolite levels.