Author

Michael Soutschek

ETH ZurichORCID 0000-0002-8472-8124Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Gerhard M. SchrattiD· 5 shared Pierre‐Luc GermainiD· 4 shared Jochen WintereriD· 3 shared Christoph DieterichiD· 2 shared David ColameoiD· 2 shared Fridolin GroßiD· 2 shared Johannes BohacekiD· 2 shared Lukas von ZiegleriD· 2 shared

Activity by Year

2021-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersNeuroscience

Gerhard M. SchrattORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A human-specific microRNA controls the timing of excitatory synaptogenesis

Michael Soutschek, Alessandra Lo Bianco, Simon Galkin, Tatjana Wüst, Koen Wentinck, David Colameo, Tomás Germade, Fridolin Groß, Lukas von Ziegler, Johannes Bohacek, Betina Elfving, Pierre‐Luc Germain, Jochen Winterer, Tatjana Kleele, Gerhard M. Schratt

The paper identifies miR-1229-3p as a human-specific microRNA that delays neuronal synaptogenesis by reducing mitochondrial metabolism.

Nature Communications · Jul 6, 2026Peer-reviewedNeuroscience

Influence of RNA circularity on Target RNA-Directed MicroRNA Degradation

Federico Fuchs Wightman, Jerónimo Lukin, Sebastián A. Giusti, Michael Soutschek, Laureano Bragado, Berta Pozzi, Paula González, Juan Pablo Fededa, Gerhard M. Schratt, Rina Fujiwara, Jeremy E. Wilusz, Damián Refojo, Manuel de la Mata

The paper investigates whether circular or linear RNA topology affects Target RNA-Directed MicroRNA Degradation (TDMD), finding that circular RNAs can inhibit while linear forms can drive TDMD.

bioRxiv · Apr 11, 2022 · PreprintMolecular Biology

microRNA-138 controls hippocampal interneuron function and short-term memory

Reetu Daswani, Carlotta Gilardi, Michael Soutschek, Prakruti Nanda, Kerstin Weiß, Silvia Bicker, Roberto Fiore, Christoph Dieterich, Pierre‐Luc Germain, Jochen Winterer, Gerhard M. Schratt

This study identifies miR-138-5p as a regulator of short-term memory and inhibitory synaptic transmission in hippocampal interneurons, with implications for schizophrenia.

eLife · Mar 15, 2022Peer-reviewedNeuroscience

scanMiR: a biochemically-based toolkit for versatile and efficient microRNA target prediction

Michael Soutschek, Fridolin Groß, Gerhard M. Schratt, Pierre‐Luc Germain

scanMiR predicts microRNA targets using a biochemical model and k-mer affinity, offering tools for binding site scanning, affinity estimation, and repression prediction.

Bioinformatics · Feb 17, 2022Peer-reviewedBioinformatics

Pervasive compartment-specific regulation of gene expression during homeostatic synaptic scaling

David Colameo, Marek Rajman, Michael Soutschek, Silvia Bicker, Lukas von Ziegler, Johannes Bohacek, Jochen Winterer, Pierre‐Luc Germain, Christoph Dieterich, Gerhard M. Schratt

This study identifies compartment-specific gene expression changes during synaptic scaling in rat hippocampal neurons, revealing distinct regulatory mechanisms in somatic and process compartments.

EMBO Reports · Aug 16, 2021Peer-reviewedNeuroscience