Mathias Lesche

This study identifies Nup153's role in repressing neuronal genes through HDAC1-mediated epigenetic regulation, influencing chromatin states and neuronal responsiveness.

The paper investigates cell lineage relationships in zebrafish fin regeneration using single-cell RNA sequencing and lineage tracing, revealing compartmentalized osteoblast and blastema contributions to bone formation.

This study identifies signaling pathways that enable the unlimited expansion of human pancreatic progenitors in defined conditions, leading to efficient and reproducible cell production for diabetes research and therapies.

This study uses multi-omics analysis of pancreatic islet donors to show heterogeneous beta cell changes associated with type 2 diabetes progression.

This study shows environmental enrichment counteracts age-related DNA methylation changes in the hippocampus of mice, preventing CpG hypomethylation at Mecp2 target sites and preserving neuronal functions.

This paper introduces a methanol-responsive polymer (MeRPy) that selectively binds and releases DNA targets, improving NGS library quality by depleting unwanted transcripts.

The paper profiles miRNAs in mouse cortical progenitors and neurons, identifying miR-486-5p as a novel regulator of neurogenesis.

The paper identifies and characterizes circRNAs in developing mouse cortical progenitor cells, revealing nearly 4,000 new circRNAs and their expression patterns.