Endothelial cell-derived, secreted long non-coding RNAs Gadlor1 and Gadlor2 aggravate pathological cardiac remodeling via intercellular crosstalk
Merve Keleş, Steve Grein, Natali Froese, Dagmar Wirth, Felix A. Trogisch, Rhys Wardman, Shruthi Hemanna, Nina Weinzierl, Philipp-Sebastian Reiners-Koch, Stefanie Uhlig, Santosh Kumar Lomada, Gesine M. Dittrich, Malgorzata Szaroszyk, Ricarda Haustein, Jan Hegermann, , Joerg Heineke
This study identifies Gadlor1 and Gadlor2 as endothelial cell-derived lncRNAs that worsen cardiac remodeling through EV-mediated crosstalk with cardiomyocytes.
Molecular Therapy — Nucleic Acids · Aug 15, 2024Peer-reviewedSystems Biology