Joerg Heineke

This study identifies mitochondrial metabolic inflexibility and S-nitrosylation remodeling in a murine HFpEF model and shows ketone supplementation partially rescues metabolic and functional defects.

This study shows that loss of eEF1A2 in cardiomyocytes causes cardiomyopathy through proteostasis defects, and mTORC1 inhibition can reverse the condition.

This study identifies Gadlor1 and Gadlor2 as endothelial cell-derived lncRNAs that worsen cardiac remodeling through EV-mediated crosstalk with cardiomyocytes.

This study shows that Ythdf2, an m6A reader protein, regulates cardiac function by controlling gene expression through its target transcripts, leading to cardiac remodeling in heart failure models.

This study identifies Rnf20's role in regulating cardiac morphogenesis and function through endothelial mechanisms, revealing its impact on extracellular matrix dynamics and angiocrine signaling.

This study shows that metformin prevents cardiac dysfunction in a mouse model of adult congenital heart disease under metabolic stress.