Author

Gregory Klein

F. Hoffmann-La Roche AGORCID 0000-0001-7571-8912Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Assay:imaging· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:trajectory inference· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alain GorielyiD· 2 shared Erik StomrudiD· 2 shared Jacob W. VogeliD· 2 shared Niklas MattssoniD· 2 shared Olof T. Strandberg· 2 shared Oskar HanssoniD· 2 shared Pavanjit ChaggariD· 2 shared Saâd JbabdiiD· 2 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Alain GorielyORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

NeurosciencebioRxivPreprintJan 29, 2026

Dynamical Aβ-Tau-Neurodegeneration Model Predicts Alzheimer's Disease Mechanisms and Biomarker Progression

Pavanjit Chaggar, Jacob W. Vogel, Travis Thompson…·Alain Goriely

The paper introduces a dynamical ATN model to simulate and predict the spatiotemporal progression of Aβ, tau, and neurodegeneration in Alzheimer's disease using multimodal imaging data.

DOI 10.64898/2026.01.27.701320

humanimaging

𝕏 PostBluesky

NeurosciencePLoS BiologyPeer-reviewedJul 21, 2025

Personalised Regional Modelling Predicts Tau Progression in the Human Brain

Pavanjit Chaggar, Jacob W. Vogel, Alexa Pichet Binette…·Alain Goriely

The paper develops a mechanistic model of tau protein dynamics using PET data to predict regional tau accumulation and disease progression stages in Alzheimer's patients.

15 citationstop 2%

humanimaging

𝕏 PostBluesky

NeuroscienceJournal of Nuclear MedicinePeer-reviewedMay 4, 2018

First in-human PET study of 3 novel tau radiopharmaceuticals: RO6958948

Dean Foster Wong, Robert A. Comley, Hiroto Kuwabara…·Edilio Borroni

This paper reports the first human PET study of three novel tau radiopharmaceuticals, finding that [18F]RO-948 shows superior characteristics for tau pathology characterization in Alzheimer's disease.

104 citationstop 1%

humanimaging

𝕏 PostBluesky