Author

Pavanjit Chaggar

Lund UniversityORCID 0000-0002-8395-3047Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:statistical model· 6 Organism:human· 5 Assay:imaging· 4 Research Focus:benchmarking· 3 Research Focus:trajectory inference· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alain GorielyiD· 5 shared Travis ThompsoniD· 4 shared Erik StomrudiD· 3 shared Jacob W. VogeliD· 3 shared Niklas MattssoniD· 3 shared Olof T. Strandberg· 3 shared Oskar HanssoniD· 3 shared Alexa Pichet BinetteiD· 2 shared

Activity by Year

2020-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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5 shared papersNeuroscience

Alain GorielyORCID

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Author profile →

6 papers

Recent·Most cited

Dynamical Aβ-Tau-Neurodegeneration Model Predicts Alzheimer's Disease Mechanisms and Biomarker Progression

Pavanjit Chaggar, Jacob W. Vogel, Travis Thompson, Roxana Aldea, Olof T. Strandberg, Erik Stomrud, Sebastian Palmqvist, Rik Ossenkoppele, Saâd Jbabdi, Stefano Magon, Gregory Klein, Alzheimer’s Disease Neuroimaging Initiative, Niklas Mattsson, Oskar Hansson, Alain Goriely

The paper introduces a dynamical ATN model to simulate and predict the spatiotemporal progression of Aβ, tau, and neurodegeneration in Alzheimer's disease using multimodal imaging data.

bioRxiv · Jan 29, 2026 · PreprintNeuroscience

Patient-specific functional brain architecture explains cortical patterns of tau PET in Alzheimer's disease

Hamid Behjat, Jacob W. Vogel, Olof T. Strandberg, Nicola Spotorno, Nicolai Franzmeier, Léa Chauveau, Jonathan Ö. Rittmo, Sara Stampacchia, Lyduine Eisa Collij, Alexa Pichet Binette, Yu Xiao, Pavan Chaggar, Zeyu Zhu, the Alzheimer's Disease Neuroimaging Initiative, Dimitri Van De Ville, , Rik Ossenkoppele

The paper shows that individual functional brain connectivity improves the explanation of tau PET patterns in Alzheimer's disease compared to group-level data.

bioRxiv · Oct 2, 2025 · PreprintNeuroscience

Personalised Regional Modelling Predicts Tau Progression in the Human Brain

Pavanjit Chaggar, Jacob W. Vogel, Alexa Pichet Binette, Travis Thompson, Olof T. Strandberg, Niklas Mattsson, Linda Karlsson, Erik Stomrud, Saâd Jbabdi, Stefano Magon, Gregory Klein, the Alzheimer’s Disease Neuroimaging Initiative, Oskar Hansson, Alain Goriely

The paper develops a mechanistic model of tau protein dynamics using PET data to predict regional tau accumulation and disease progression stages in Alzheimer's patients.

PLoS Biology · Jul 21, 2025Peer-reviewedNeuroscience

Neuronal activity and amyloid-beta cause tau seeding in the entorhinal cortex in Alzheimer's disease

Christoffer G. Alexandersen, Danielle S. Bassett, Alain Goriely, Pavanjit Chaggar, the Alzheimer’s Disease Neuroimaging Initiative

The paper uses a computational model to show neuronal activity and amyloid-beta drive tau seeding in the entorhinal cortex, linking these factors to early Alzheimer's disease pathology.

bioRxiv · Mar 7, 2025 · PreprintNeuroscience

Braiding Braak and Braak: Staging patterns and model selection in network neurodegeneration

Prama Setia Putra, Travis Thompson, Pavanjit Chaggar, Alain Goriely, for the Alzheimer’s Disease Neuroimaging Initiative

The paper introduces a method using braid diagrams to analyze staging patterns in neurodegenerative diseases and shows how model choices affect staging outcomes.

Network Neuroscience · Jan 1, 2021Peer-reviewedNeuroscience

Protein-protein interactions in neurodegenerative diseases: a conspiracy theory.

Travis Thompson, Pavanjit Chaggar, Ellen Kuhl A, Alain Goriely, Alzheimer’s Disease Neuroimaging Initiative

The paper develops a coupled network-based model to study interactions between amyloid-beta and tau proteins in neurodegenerative diseases, revealing their cooperative role in disease propagation.

PLoS Computational Biology · Oct 13, 2020Peer-reviewedNeuroscience