RyR2-Dependent Calcium Leak Drives the Acute Cardiovascular Manifestations of Ciguatera Poisoning: implications for an emerging climate-sensitive cardiotoxic disease
Hugo Benoit, Ismael Choukri, Pierre Sicard, Elisa Bounasri, Gilles Labesse, Laurie Alburquerque, Mohamed Laabir, Jacques G. Mercier, Jérôme Thireau, Alain Lacampagne, Albano C. Méli
This study identifies RyR2-dependent calcium leak as a mechanism underlying acute cardiovascular effects of ciguatoxin poisoning in human cardiomyocytes and rats.
bioRxiv · Sep 4, 2026 · PreprintPhysiology