Jérôme Thireau

RyR2-Dependent Calcium Leak Drives the Acute Cardiovascular Manifestations of Ciguatera Poisoning: implications for an emerging climate-sensitive cardiotoxic disease

This study identifies RyR2-dependent calcium leak as a mechanism underlying acute cardiovascular effects of ciguatoxin poisoning in human cardiomyocytes and rats.

A novel mouse model of hypertensive emergency with multiorgan microvascular disease implicating the VEGFA/sFlt-1 balance

This study develops a mouse model of hypertensive emergency with multiorgan microvascular disease and identifies dysregulated VEGFA/sFlt-1 signaling as a key driver.

High-Resolution Ultrasound and Speckle Tracking: a non-invasive approach to assess in vivo gastrointestinal motility during development

This study uses high-resolution ultrasound and speckle tracking to visualize and quantify fetal gastrointestinal motility in chick embryos, showing synchronized contractions develop late in fetal life.