Gilles Labesse

This study identifies RyR2-dependent calcium leak as a mechanism underlying acute cardiovascular effects of ciguatoxin poisoning in human cardiomyocytes and rats.

The paper characterizes the regulatory mechanism of class II bacterial IMPDH from Burkholderia thailandensis, showing MgGTP's dual role in enzyme activity and oligomerization.

The paper identifies a conserved helical motif in DCAF7 partners using structural and computational methods, revealing its role in scaffolding and linking to neurodevelopmental disorders.

This study functionally and structurally characterizes APH(3')-IIb, an enzyme from Pseudomonas aeruginosa that confers resistance to aminoglycoside antibiotics.

This study uses deep-learning structural modeling and divergence dating to analyze RdRps from plant and fungal viruses, revealing a recent divergence of sobelivirads and suggesting cross-kingdom host shifts in their evolutionary history.

SLiMAn is a web server that analyzes short linear motifs in interactomics data to predict and visualize SLiM-recognition domain pairings.

The paper evaluates the conformational space of the estrogen receptor alpha (ER) using crystal structures, molecular dynamics, and virtual screening to inform drug design.

This study identifies molecular determinants controlling Arpp19 phosphatase-inhibitory activity and reveals a feedback loop between two phosphorylation sites.

The paper develops a method for predicting ligand affinities using structural ensembles and docking metrics, showing improved accuracy when combining structure-based and ligand-based features.