Author

Zi Wen

Huazhong Agricultural UniversityORCID 0000-0001-7600-4399Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Assay:ChIP-seq· 2 Approach:deep learning· 2 Organism:virus· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Li LiiD· 3 shared Dehua LuoiD· 2 shared Dengguo WeiiD· 2 shared Jinsheng XuiD· 2 shared Yingxiang Deng· 2 shared Zhiyuan HuangiD· 2 shared Chunhui HouiD· 1 shared Fan WangiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBioinformatics

Li LiORCID

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4 papers

Recent·Most cited

MicrobiologyMolecular Systems BiologyPeer-reviewedJul 30, 2026

RNA Architecture Underlies Discontinuous Transcription and Evolution of Coronavirus

Zi Wen, Lei Chen, Dehua Luo…·Dengguo Wei

This study identifies RNA-RNA interactions and non-canonical sgRNAs in coronaviruses, revealing their role in transcription regulation and immune evasion.

DOI 10.1038/s44320-026-00239-0

virusbulk RNA-seq

𝕏 PostBluesky

GenomicseLifePeer-reviewedJul 2, 2025

Exploiting functional regions in the viral RNA genome as druggable entities

Dehua Luo, Yingge Zheng, Zhiyuan Huang…·Dengguo Wei

The paper applies SHAPE-MaP to identify functional RNA structures in PEDV to guide antiviral drug design.

DOI 10.7554/elife.103923.3

viruslong-read sequencing

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BioinformaticsGenomics Proteomics & BioinformaticsPeer-reviewedDec 1, 2024

COCOA: A Framework for Fine-scale Mapping Cell-type-specific Chromatin Compartmentalization Using Epigenomic Information

Kai Li, Ping Zhang, Jinsheng Xu…·Li Li

COCOA infers fine-scale chromatin compartment patterns from histone modifications, showing accurate results and cell-type-specific predictions.

DOI 10.1093/gpbjnl/qzae091

Hi-CChIP-seq

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BioinformaticsbioRxivPreprintSep 17, 2021

Extensive Chromatin Structure-Function Association Revealed by Accurate Compartmentalization Characterization

Zi Wen, Weihan Zhang, Quan Zhong…·Li Li

The paper introduces MOSAIC, a method to detect chromatin compartments, revealing micro-compartments that improve understanding of chromatin structure-function relationships.

DOI 10.1101/2021.09.17.460762

humanChIP-seq

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