Li Li

RNA Architecture Underlies Discontinuous Transcription and Evolution of Coronavirus

This study identifies RNA-RNA interactions and non-canonical sgRNAs in coronaviruses, revealing their role in transcription regulation and immune evasion.

COCOA: A Framework for Fine-scale Mapping Cell-type-specific Chromatin Compartmentalization Using Epigenomic Information

COCOA infers fine-scale chromatin compartment patterns from histone modifications, showing accurate results and cell-type-specific predictions.

Extensive Chromatin Structure-Function Association Revealed by Accurate Compartmentalization Characterization

The paper introduces MOSAIC, a method to detect chromatin compartments, revealing micro-compartments that improve understanding of chromatin structure-function relationships.

Systematic Chromatin Architecture Analysis in Xenopus tropicalis Reveals Conserved Three-Dimensional Folding Principles of Vertebrate Genomes

This study analyzes chromatin architecture in Xenopus tropicalis, revealing TAD formation dynamics and conserved CTCF-Rad21 orientation patterns across vertebrates.

Resolving a Systematic Error in STARR-seq for QuantitativeEnhancer Activity Mapping

The paper identifies a systematic error in STARR-seq for enhancer activity measurement in Arabidopsis thaliana and proposes a solution using specialized primers to recover self-transcripts, revealing new insights into enhancer function.

Global Quantitative Mapping of Enhancers in Rice Genome by STARR-seq

The paper quantitatively identifies enhancers in the rice genome using STARR-seq and reports their genomic locations and epigenetic features.

Amplification-free Library Preparation Improves Quality of Hi-C Analysis

This paper introduces an amplification-free Hi-C library preparation method that improves chromatin interaction quality and reduces sequencing depth requirements.