Robert Vácha

This paper introduces a domain decomposition method to quantify mixing in disordered protein simulations, showing physicochemical similarity promotes mixing and identifying factors influencing condensate formation.

The paper identifies sequence features of α-helical peptides that reduce membrane line tension through computational simulations and evolutionary optimization.

This study uses multiscale simulations and X-ray scattering to quantify membrane strain caused by protein inclusions in proteoliposomes, showing agreement between simulations and experiments.

This paper develops a cell-permeable Biotin-HaloTag ligand to enable sequential labeling and separation of distinct protein variants for functional studies.

gorder calculates lipid order parameters from molecular simulations, offering a comprehensive and user-friendly tool for various membrane systems and force fields.

This study identifies two mechanisms by which RECQ5 modulates RNA polymerase II transcription: attenuating elongation via the brake helix and forming a condensate scaffold matrix.

This study uses molecular dynamics simulations to show that displacing divalent ions in Gram-negative bacterial membranes affects polymyxin permeability and resistance.