Marek Šebesta

This study identifies distinct peripheral elements in senataxin that mediate R-loop unwinding and RNA polymerase II regulation through structural and biochemical analyses.

This study identifies two mechanisms by which RECQ5 modulates RNA polymerase II transcription: attenuating elongation via the brake helix and forming a condensate scaffold matrix.

This study investigates how the BRCA1-BARD1 complex interacts with phosphorylated RNAPII CTD through BRCT repeats, revealing its role in RNAPII condensation and transcription-DNA repair coordination.

The paper identifies the tetrameric INTS6-SOSS1 complex as essential for DNA:RNA hybrid autoregulation at double-strand breaks, facilitating DNA repair through PP2A recruitment and DARTs prevention.

The paper shows that Mus81 and Yen1 cleave D-loops to form half-crossover precursors in budding yeast.

This study characterizes the structural and functional interaction between influenza A virus RNA polymerase and host RNA Polymerase II CTD, identifying key residues and their roles in transcription and replication.

The paper shows that the SOSS1 complex and RNA polymerase II form phase-separated compartments at double-strand breaks to facilitate DNA repair.

This study identifies the DExD/H helicase domain of Dicer as critical for accurate miRNA biogenesis, showing its role in substrate recognition, cleavage, and strand selection in mammals.