Paula J. van der Meer

The paper shows that helicase-deficient TFIIH causes severe disease by trapping DNA in a futile repair cycle, leading to persistent excision without lesion removal.

This study identifies STK19 as a factor facilitating the transition from initial TCR complex assembly to downstream repair steps by enabling RNAPII clearance.

This study identifies a selective RNAPII clearance defect in Cockayne syndrome cells, linking it to neurodegeneration rather than DNA repair failure.