Author

Ryan R. Cupo

University of PennsylvaniaORCID 0000-0001-7639-1923Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

James ShorteriD· 2 shared Korrie L. MackiD· 2 shared Aaron D. GitleriD· 1 shared Alice Flynn Ford· 1 shared Ashkan JavaherianiD· 1 shared Ashmita Baral· 1 shared Bo Lim Lee· 1 shared Bradley Class· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

James ShorterORCID

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2 papers

Recent·Most cited

Molecular BiologyCell ReportsPeer-reviewedJan 1, 2025

Opposing roles of p38α phosphorylation and arginine methylation in driving TDP-43 proteinopathy.

Mari Aikio, Hana M. Odeh, Heike J. Wobst…·James Shorter

This study identifies opposing roles of p38α phosphorylation and arginine methylation in TDP-43 proteinopathy, showing that phosphorylation promotes aggregation while methylation reduces it.

20 citationstop 1%

humanproteomics

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BiochemistrybioRxivPreprintJan 11, 2024

Defining a small-molecule stimulator of the human Hsp70-disaggregase system with selectivity for DnaJB proteins

Edward Chuang, Ryan R. Cupo, Jeffrey R. Bevan…·James Shorter

The paper identifies a small-molecule stimulator of the human Hsp70-disaggregase system that selectively activates DnaJB1- or DnaJB4-containing chaperone complexes.

4 citations

humanexperimental assay

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