Manufacture of Clostridioides difficile spores for experimental infection of human volunteers
Annefleur D. O. Hensen, Céline Harmanus, Christine Voorvelt, Anoecim Robecca Geelen, Maryam El Hamdioui, Ed J. Kuijper, Laura Pattacini, Pim Schipper, Inge M. van Amerongen-Westra, Pauline Meij, M. Y. Eileen C. van der Stoep, Meta Roestenberg, Wiep Klaas Smits
This paper describes a GMP-compliant process for producing C. difficile spores for use in controlled human infection models.
The Journal of Infectious Diseases · Dec 3, 2025Peer-reviewedMicrobiology