Author

Meta Roestenberg

Leiden UniversityORCID 0000-0002-5052-2830Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Organism:C. elegans· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Céline HarmanusiD· 2 shared Cornelis Hendrik HokkeiD· 2 shared Ed J. KuijperiD· 2 shared Wiep Klaas SmitsiD· 2 shared Aarti JainiD· 1 shared Alejandro Ramírez· 1 shared Alexey SergushicheviD· 1 shared Algis Jasinskas· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

Céline HarmanusORCID

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5 papers

Recent·Most cited

O-GlcNAcylation and low glycolysis underpin Th2 polarization by dendritic cells

Leonard R. Pelgrom, Marjolein Quik, José Javier Fernández, Thiago A. Patente, Graham A. Heieis, Alexey Sergushichev, Jie Kang, Xiaobo Wang, Justine Dontaine, Marie-Sophie Fabre, Frank Otto, Alwin J. van der Ham, Lisa W. Bloemberg, Marion H. König, Béatrice M. F. Winkel, , Bart Everts

This study identifies O-GlcNAcylation and reduced glycolysis as key factors in Th2 polarization by dendritic cells, showing their role in immune synapse regulation and TCR signaling.

bioRxiv · Feb 5, 2026 · PreprintImmunology

Characterization of the clade 4 non-toxigenic C. difficile isolate L-NTCD03 carrying the cfr(B) gene

Britt Nibbering, Sam Nooij, Céline Harmanus, Ingrid M. J. G. Sanders, Inez M. Miedema, Quinten R. Ducarmon, Rolf H. A. M. Vossen, Susan L. Kloet, Colleen K. Ardis, Robert A. Britton, Farnaz Yousefi, Jenna E. Bayne, Chandrashekhar Charavaryamath, Andy Y. Law, Morgan L. Murphy, , Wiep Klaas Smits

The paper characterizes a non-toxigenic C. difficile strain, L-NTCD03, showing antimicrobial resistance and non-toxicity, suggesting its potential as a live biotherapeutic.

FEMS Microbes · Jan 1, 2026Peer-reviewedMicrobiology

Manufacture of Clostridioides difficile spores for experimental infection of human volunteers

Annefleur D. O. Hensen, Céline Harmanus, Christine Voorvelt, Anoecim Robecca Geelen, Maryam El Hamdioui, Ed J. Kuijper, Laura Pattacini, Pim Schipper, Inge M. van Amerongen-Westra, Pauline Meij, M. Y. Eileen C. van der Stoep, Meta Roestenberg, Wiep Klaas Smits

This paper describes a GMP-compliant process for producing C. difficile spores for use in controlled human infection models.

The Journal of Infectious Diseases · Dec 3, 2025Peer-reviewedMicrobiology

Pre-clinical studies of Schistosoma mansoni vaccines: a scoping review

Emma L. Houlder, Lucas Ferreira da Silva, Angela van Diepen, Murilo Sena Amaral, Robert Alan Wilson, Cornelis Hendrik Hokke, Meta Roestenberg, Wilfried A.M. Bakker

This paper reviews pre-clinical Schistosoma mansoni vaccine studies, finding that only two antigens achieved over 90% efficacy, but most vaccines fall short of required thresholds due to variable formulations and study designs.

PLoS neglected tropical diseases · Jun 2, 2025Peer-reviewedImmunology

Correlative humoral and cellular immunity to genetically attenuated malaria parasites in humans

Emil Colstrup, Rie Nakajima, Jelte M. M. Krol, Olivia A. C. Lamers, Rafael Ramiro de Assis, Aarti Jain, Algis Jasinskas, E. Iliopoulou, Helena M. de Bes-Roeleveld, Blandine M. D. Franke-Fayard, Meta Roestenberg, Philip Louis Felgner, Rajagopal Murugan

This study examines humoral and cellular immunity to genetically attenuated malaria parasites in humans and identifies key liver-stage antigens for vaccine development.

iScience · May 5, 2025Peer-reviewedImmunology