Daniel Alvarez‐Fischer

This study identifies Foxo3 as a key regulator of dopaminergic vulnerability through microglial mechanisms, showing that baseline microglial state, rather than acute transcriptional responses, determines neurodegeneration in Parkinson's disease.

The paper uses single-nucleus RNA sequencing to identify cell type-specific dysregulation in Parkin-deficient neuron-microglia co-cultures, revealing distinct pathway disturbances in dopaminergic neurons and microglia.

This study shows that OTX2 synthesized in the choroid plexus and secreted into cerebrospinal fluid regulates anxiety-like behaviors in mice through non-cell-autonomous mechanisms.