Anne-Laure Iscache

The paper uses single-cell RNA sequencing to analyze immune cell interactions in asymptomatic and symptomatic malaria patients, finding reduced monocyte-T cell interactions and increased inflammation in symptomatic cases.

This study shows that sustained antigenic engagement leads to multidimensional remodeling and functional diversification of CTLs, maintaining cytotoxic activity while creating functionally distinct states.

This study shows that human CTLs sustain cytotoxicity by selectively replenishing granzyme B through de novo synthesis, maintaining its activity and supporting prolonged killing.

This study identifies Foxo3 as a key regulator of dopaminergic vulnerability through microglial mechanisms, showing that baseline microglial state, rather than acute transcriptional responses, determines neurodegeneration in Parkinson's disease.