Bárbara Domingues Bitarello

Host Cellular Remodeling, Not Viral Transcriptional Inhibition, Drives Quorum Sensing Signal-Mediated Evasion of Viral Lysis in Gephyrocapsa huxleyi

The paper shows that HHQ enables Gephyrocapsa huxleyi to evade viral lysis by remodeling host processes, not by inhibiting viral transcription.

A hierarchical Bayesian framework accommodates intraspecific and interspecific variation in multivariate traits

The paper introduces a hierarchical Bayesian framework to estimate taxon-specific intraspecific covariance structures and evolutionary processes for multivariate traits, showing improved uniformity in evolutionary rate estimates across the great ape clade.

Principal Components Analysis fails to recover phylogenetic structure in hominins

This paper shows that PCA fails to recover phylogenetic structure in hominin datasets, highlighting flaws in using PCA for phylogenetic inference.

Assessing phylogenetic information content and redundancy in hominin craniodental traits

The paper evaluates the phylogenetic information content of hominin craniodental traits and finds that only 31 traits contribute meaningfully to phylogenetic inference.

Genetically influenced tobacco and alcohol use behaviors impact erythroid trait variation

This study uses Mendelian randomization to show that genetic predisposition to smoke tobacco indirectly reduces red blood cell count by increasing alcohol intake.

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.

This study identifies 43 genomic loci associated with reproductive success in 785,604 individuals, showing ongoing natural selection at the FADS locus.

Assessing the risk stratification of breast cancer polygenic risk scores in two Brazilian samples

This study evaluates the transferability of a breast cancer polygenic risk score in two Brazilian admixed cohorts compared to UK Biobank data, finding inflated PRS distributions and equivalent predictive power in case-control comparisons.

Polygenic scores for height in admixed populations

This paper evaluates how well polygenic scores for height predict traits in admixed populations and identifies ancestry-related factors affecting their accuracy.

Functional and evolutionary impact of polymorphic inversions in the human genome

The paper studies 45 common human polymorphic inversions, showing their functional and evolutionary impact, including gene disruption and association with phenotypic traits.

Signatures of long-term balancing selection in human genomes

The paper introduces NCD2, a statistic to detect long-term balancing selection in human genomes, finding it affects 0.6% of genomic windows and 0.8% of positions, with many novel targets.

Mapping bias overestimates reference allele frequencies at the HLA genes in the 1000 Genomes Project phase I data

The paper evaluates genotype calls and allele frequency estimates at HLA genes in 1000 Genomes Project data, finding significant overestimation of reference allele frequencies due to mapping bias.