Assessing the risk stratification of breast cancer polygenic risk scores in two Brazilian samples
Rodrigo Barreiro, Tatiana Ferreira de Almeida, Catarina dos Santos Gomes, Frederico Monfardini, Allysson Allan de Farias, Gabriela Chiuffa Tunes, GM Souza, Etienne Duim, JS Correia, Antônio Victor Campos Coelho, Marcel Pinheiro Caraciolo, YAO Duarte, Mayana Zatz, Edson Amaro, JB Oliveira, , Michel Satya Naslavsky
This study evaluates the transferability of a breast cancer polygenic risk score in two Brazilian admixed cohorts compared to UK Biobank data, finding inflated PRS distributions and equivalent predictive power in case-control comparisons.
medRxiv · Sep 9, 2022 · PreprintGenetic & Genomic Medicine