High Resolution Spatial Mapping of Microbiome-Host Interactions via in situ Polyadenylation and Spatial RNA Sequencing
Ioannis Ntekas, Lena Takayasu, David W. McKellar, Benjamin Grodner, Chase Holdener, Peter A. Schweitzer, Maya Sauthoff, Qiaojuan Shi, Ilana Brito, Iwijn De Vlaminck
The paper introduces a method to map microbiome-host interactions in the gut at high spatial resolution using in situ polyadenylation and spatial RNA sequencing, revealing microbial biogeography and host-microbe interactions in a mouse model.
bioRxiv · Nov 18, 2024 · PreprintGenomics