David W. McKellar

Size-Modulated Mesoderm-Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

This study uses micropatterned cardioids to investigate mesoderm-endoderm interactions in heart development, finding that pattern size affects cavity formation and signaling.

High Resolution Spatial Mapping of Microbiome-Host Interactions via in situ Polyadenylation and Spatial RNA Sequencing

The paper introduces a method to map microbiome-host interactions in the gut at high spatial resolution using in situ polyadenylation and spatial RNA sequencing, revealing microbial biogeography and host-microbe interactions in a mouse model.

Hedgehog signaling via its ligand DHH acts as cell fate determinant during skeletal muscle regeneration

This study identifies DHH as a key ligand in the Hedgehog signaling pathway that regulates fibro/adipogenic progenitor fate during skeletal muscle regeneration, preventing adipogenesis and promoting fibrosis.

Spatiotemporal transcriptomics reveals pathogenesis of viral myocarditis

This study uses spatiotemporal transcriptomics to map reovirus-induced myocarditis in neonatal mice, revealing immune responses and cellular interactions in the heart and intestine.

In situ polyadenylation enables spatial mapping of the total transcriptome

This paper introduces a method to spatially map the total transcriptome by enabling detection of non-polyadenylated RNAs through in situ polyadenylation.

Uncovering Transcriptional Dark Matter via Gene Annotation Independent Single-Cell RNA Sequencing Analysis

The paper introduces a method to uncover transcriptionally active regions in scRNA-seq data beyond standard gene annotations, improving transcriptome coverage in understudied organisms.

Spatiotemporal single-cell RNA sequencing of developing hearts reveals interplay between cellular differentiation and morphogenesis

This study uses spatiotemporal single-cell RNA sequencing to analyze chicken heart development, revealing the interplay between cellular differentiation and morphogenesis.

Strength in numbers: Large-scale integration of single-cell transcriptomic data revealsrare, transient muscle progenitor cell states in muscle regeneration

The paper integrates large-scale single-cell and spatial transcriptomic data to identify rare, transient muscle progenitor cell states involved in muscle regeneration.