Author

Kwang-Seok Lee

German Cancer Research CenterORCID 0000-0001-7682-5736Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Claudia ScholliD· 2 shared Stefan FröhlingiD· 2 shared Andreas PlückthuniD· 1 shared Anna KuntzeiD· 1 shared Asli KayseriliiD· 1 shared Bianca AltvateriD· 1 shared Birgit DreieriD· 1 shared Charles S. UmbaughiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Claudia SchollORCID

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2 papers

Recent·Most cited

Cancer BiologyScience AdvancesPeer-reviewedSep 3, 2025

Selective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma

Charles S. Umbaugh, Marie Groth, Cihan Erkut…·Claudia Scholl

This study uses T-DARPins to inhibit TBXT in chordoma cells, revealing its regulome and identifying therapeutic vulnerabilities, including sensitivity to JAK2 inhibitors.

5 citations

humanproteomics

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Cancer BiologyClinical Cancer ResearchPeer-reviewedAug 29, 2024

Exploiting WEE1 kinase activity as FUS::DDIT3-dependent therapeutic vulnerability in myxoid liposarcoma

Lorena Heinst, Kwang-Seok Lee, Ruth Berthold…·Marcel Trautmann

This study identifies WEE1 kinase activity as a therapeutic target in FUS::DDIT3-driven myxoid liposarcoma by showing its role in replication stress tolerance and cell survival.

2 citations

humanexperimental assay

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