This study shows that parental intermittent fasting induces intergenerational molecular changes in the brain, affecting sensory pathways and sex-dependent gene expression in offspring.

bioRxiv · Oct 19, 2026 · PreprintGenomics

Uncovering Shared and Tissue-Specific Molecular Adaptations to Intermittent Fasting in Liver, Brain, and Muscle

Yibo Fan, Senuri De Silva, Nishat I Tabassum, Xiangyuan Peng, Vernise JT Lim, Xiangru Cheng, Keshava K. Datta, Rohan G. T. Lowe, Terrance G. Johns, Mark P. Mattson, Suresh Mathivanan, Christopher Graeme Sobey, Eitan Okun, Yong Liu, Guobing Chen, , Thiruma Valavan Arumugam

This study identifies tissue-specific and shared molecular adaptations to intermittent fasting in liver, brain, and muscle using proteomics and transcriptomics.

eLife · Apr 17, 2026Peer-reviewedMolecular Biology

Intermittent Fasting Reprograms Chromatin Accessibility to Modulate Gene Expression in Brain and Muscle

Yibo Fan, Xiangyuan Peng, Mansour Ebrahimi, Nishat I Tabassum, Xiangru Cheng, Yatendra Kumar, Yong Liu, Guobing Chen, Eitan Okun, Terrance G. Johns, Christopher Graeme Sobey, Mitchell K.P. Lai, Jayantha Gunaratne, Mark P. Mattson, Dong‐Gyu Jo, Thiruma Valavan Arumugam

This study shows intermittent fasting changes chromatin accessibility and gene expression in brain and muscle tissues of mice, affecting metabolic and functional pathways.

bioRxiv · Feb 11, 2025 · PreprintBioinformatics

Impact of Parental Time-Restricted Feeding on Offspring Metabolic Phenotypic Traits

Yibo Fan, Xiangyuan Peng, Nishat I Tabassum, Xiangru Cheng, Sharmelee Selvaraji, Vivian Tran, Tayla A. Gibson Hughes, Buddhila Wickramasinghe, Abdulsatar Jamal, Quynh Nhu Dinh, Mathias Gelderblom, Grant Raymond Drummond, Christopher Graeme Sobey, Jim Penman, Terrance G. Johns, , Thiruma Valavan Arumugam

This study shows that parental time-restricted feeding affects offspring metabolic traits differently in males and females, offering protection against diet-induced metabolic issues.

International Journal of Biological Sciences · Feb 10, 2025Peer-reviewedGenetics

TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration

Manling Xie, Yong Liu, Shunyi Zhao, Lingxin Zhang, Dale B. Bosco, Yuan‐Ping Pang, Jun Zhong, Udit Sheth, Yuka A. Martens, Na Zhao, Chia‐Chen Liu, Yongxian Zhuang, Liewei Wang, Dennis W. Dickson, Mark P. Mattson, , Long‐Jun Wu

This study identifies a novel interaction between TREM2 and TDP-43, showing TREM2 mediates microglial neuroprotection against TDP-43-related neurodegeneration.

Nature Neuroscience · Dec 16, 2021Peer-reviewedNeuroscience

Multiomics Analyses Reveal Dynamic Bioenergetic Pathways and Functional Remodeling of the Heart During Intermittent Fasting

Thiruma Valavan Arumugam, Asfa Alli Shaik, Elisa Anamaria Liehn, Sharmelee Selvaraji, Luting Poh, Vismitha Rajeev, Yoonsuk Cho, Yong Eun Cho, Jong-Ho Kim, Joonki Kim, Hannah L. F. Swa, David Tan Zhi Hao, Chutima Rattanasopa, David Yang‐Wei Fann, David Castano Mayan, , Jayantha Gunaratne

This study uses multi-omics analyses to investigate how different intermittent fasting regimens affect heart function and molecular pathways in mice.

bioRxiv · Mar 4, 2021 · PreprintSystems Biology

Astrocyte- and neuron-derived extracellular vesicles from Alzheimer's disease patients effect complement-mediated neurotoxicity

Carlos J. Nogueras‐Ortiz, Vasiliki Mahairaki, Francheska Delgado‐Peraza, Debamitra Das, Konstantinos Ioannis Avgerinos, Erden Eren, Matthew B Hentschel, Edward J. Goetzl, Mark P. Mattson, Dimitrios Kapogiannis

The paper tests whether Alzheimer's disease patient-derived extracellular vesicles induce complement-mediated neurotoxicity in neurons.

Cells · Jul 4, 2020Peer-reviewedNeuroscience

Integrative Epigenomic and Transcriptomic Analysis Reveals Robust Metabolic Switching in the Brain During Intermittent Fasting

Gavin Yong-Quan Ng, Dominic Paul Lee Kok Sheng, Sung Wook Kang, David Yang‐Wei Fann, Joonki Kim, Asfa Alli Shaik, Yoon Suk Cho, Jihoon Han, Jae Hoon Sul, Vardan T. Karamyan, Eitan Okun, Shaikali Thameem Dheen, Manoor Prakash Hande, Raghu Vemuganti, Karthik Babu Mallilankaraman, , Thiruma Valavan Arumugam

This study shows intermittent fasting modulates H3K9me3 epigenetic marks and transcriptomic changes in mouse cerebellum, with lasting effects after refeeding.

bioRxiv · Mar 22, 2020 · PreprintNeuroscience