Grant Raymond Drummond

This study shows that parental intermittent fasting induces intergenerational molecular changes in the brain, affecting sensory pathways and sex-dependent gene expression in offspring.

This study shows that cytotoxic γδ-T cells contribute to cardiomyocyte death after myocardial infarction, and targeting STING and type I interferon pathways reduces infarct size.

This study shows that S100A8/A9 inhibition reduces splenic myelopoiesis and improves stroke outcomes by decreasing neutrophilia and infarct size.

This study identifies marginal zone B cells as antigen-responsive subsets that amplify immune responses in hypertension through clonal expansion and intercellular communication with CD8+ T cells.

This study identifies a novel fibroblast subcluster, Fibro-Cthrc1, as a driver of aortic fibrosis in hypertension using scRNA-seq and validates its association with blood pressure in humans.

This study shows that parental time-restricted feeding affects offspring metabolic traits differently in males and females, offering protection against diet-induced metabolic issues.

This study shows that intermittent fasting reduces neurovascular damage and oxidative stress in a mouse model of vascular dementia.

This study compares hippocampal gene expression in young and old mice under chronic hypoperfusion and aging, identifying shared molecular pathways linked to vascular dementia.

This study uses multi-omics analyses to investigate how different intermittent fasting regimens affect heart function and molecular pathways in mice.

This study shows that AIM2 inflammasome activation contributes to brain injury and cognitive impairment in a mouse model of vascular dementia.

This study shows intermittent fasting modulates H3K9me3 epigenetic marks and transcriptomic changes in mouse cerebellum, with lasting effects after refeeding.