Anne E. Dodson

TRACE identifies tumor-reactive CD8+ T cells across solid tumors using clonotype-level classification and scRNA-seq data, showing high accuracy and specificity for tumor-experienced T cells.

This study identifies Regnase-1 and SOCS1 dual-inactivation as a strategy to enhance anti-tumor functionality of CD8+ T cells by rewiring their differentiation and effector state.

This study predicts HRD in 1,332 cancer and 84 non-cancer cell lines using CHORD and HRDsum, finding BRCA1/2 mutations and epigenetic silencing as key predictors.

The paper shows that pUG tails on RNAs enable transgenerational epigenetic inheritance by promoting gene silencing through siRNA synthesis in C. elegans.

The paper shows that germ granule disruption in C. elegans leads to transgenerational RNAi defects through aberrant siRNA propagation and silencing.