Daniel J. Pagano

The paper identifies tissue-specific transposon regulation mechanisms in C. elegans, showing that the germline and soma use distinct RNAi pathways and novel factors to control Tc1 transposition.

The paper identifies a DNA repair strategy in C. elegans somatic cells that significantly increases transposon mobilization rates compared to germline cells.

The paper shows that pUG tails on RNAs enable transgenerational epigenetic inheritance by promoting gene silencing through siRNA synthesis in C. elegans.

This paper identifies HERI-1 as a protein that limits RNAi inheritance in C. elegans by regulating the nuclear RNAi pathway.