Viral RNA pUGylation Promotes Antiviral Immunity in C. elegans
David D. Lowe, Aditi Shukla, Scott G. Kennedy
This study shows that pUGylation of viral RNAs by RDE-3 in C. elegans promotes antiviral immunity by enabling RdRP-based siRNA production.
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Whitehead Institute for Biomedical ResearchORCID 0000-0001-9743-4128Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
David D. Lowe, Aditi Shukla, Scott G. Kennedy
This study shows that pUGylation of viral RNAs by RDE-3 in C. elegans promotes antiviral immunity by enabling RdRP-based siRNA production.
Michelle L. Peters, Aditi Shukla, Zoe A. Gotthold…·Sebastian Lourido
This study identifies how 5' UTR features and upstream AUGs regulate translation efficiency in Toxoplasma gondii using ribosome profiling and synthetic reporter assays.
Michael W. Stubna, Aditi Shukla, David P. Bartel
The paper identifies 22 C. elegans miRNAs destabilized by EBAX-1 loss, showing TDMD is a major miRNA-destabilization pathway with variable 3' sequence dependence.
Aditi Shukla, Roberto Perales, Scott G. Kennedy
The paper shows that piRNAs prevent permanent gene silencing by inhibiting the pUG RNA/siRNA cycle in C. elegans.
Aditi Shukla, Jenny Jiacheng Yan, Daniel J. Pagano…·Scott G. Kennedy
The paper shows that pUG tails on RNAs enable transgenerational epigenetic inheritance by promoting gene silencing through siRNA synthesis in C. elegans.