Author

Tycho Marinus

University of GroningenORCID 0000-0001-7723-0961Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Genetics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:drug response / drug discovery· 1 Approach:graph neural network· 1 Assay:long-read sequencing· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Aditi Narendra BorkariD· 1 shared Alex Childs· 1 shared Almudena Ponce-SalvatierraiD· 1 shared Chandran NithiniD· 1 shared Danny IncarnatoiD· 1 shared Dinh Thien Kim Ly· 1 shared Eric J. SnijderiD· 1 shared Eyal Dafni· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperBiophysics

Aditi Narendra BorkarORCID

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3 papers

Recent·Most cited

BiophysicsbioRxivPreprintOct 28, 2026

Comparative analysis identifies a shared topological organisation among divergent intergenic RNAs

Alex Childs, Dinh Thien Kim Ly, Tycho Marinus…·Aditi Narendra Borkar

The paper identifies a shared topological organisation in divergent arenavirus intergenic RNAs using graph theory and structural analysis.

DOI 10.64898/2026.10.22.760956

graph neural networkstatistical model

𝕏 PostBluesky

MicrobiologyJournal of Structural Biology XPeer-reviewedDec 19, 2025

Alanine-scanning of the yeast killer toxin K2 reveals key residues for activity, gain-of-function variants, and supports prediction of precursor processing and 3D structure.

Rianne C. Prins, Tycho Marinus, Eyal Dafni…·Sonja Billerbeck

This study uses alanine scanning and computational methods to map sequence-function relationships in the yeast killer toxin K2, revealing key residues for activity and enabling engineering of enhanced toxicity and specificity.

5 citations

yeastprotein structure

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GeneticsNucleic Acids ResearchPeer-reviewedOct 22, 2020

Genome-wide mapping of therapeutically-relevant SARS-CoV-2 RNA structures

Ilaria Manfredonia, Chandran Nithin, Almudena Ponce-Salvatierra…·Danny Incarnato

This study maps SARS-CoV-2 RNA structures at single-base resolution using SHAPE-MaP, identifies druggable pockets and conserved elements, and highlights targets for antisense therapeutics.

283 citationstop 1%

long-read sequencingexperimental assay

𝕏 PostBluesky