Eric J. Snijder

The paper models the arterivirus nsp2 and nsp3 proteins to identify conserved structural features of DMV pores, revealing their role in RNA export and viral replication.

This study identifies conserved double-membrane-spanning RNA export pores in arterivirus and coronavirus replication organelles, showing their role in RNA export and encapsidation.

The paper develops bi-substrate inhibitors of SARS-CoV-2 nsp14 methyltransferase using structure-guided design, achieving nanomolar potency but limited cellular antiviral activity.

This study shows that inhibiting ACC disrupts MERS-CoV particle release but not replication organelle formation, highlighting ACC as a potential antiviral target.

ASOs (LNA gapmers) targeting the SARS-CoV-2 RNA genome effectively reduce viral RNA load by up to 96% in vitro.

This study identifies critical residues in the nsp14 N7-MTase domain essential for betacoronavirus replication and suggests potential drug targets.

This study maps SARS-CoV-2 RNA structures at single-base resolution using SHAPE-MaP, identifies druggable pockets and conserved elements, and highlights targets for antisense therapeutics.