Olivier Goureau

This study compares human iPSC-derived photoreceptors of different ages for transplantation into a mouse retinal degeneration model, showing structural integration and functional maturation.

The paper develops and evaluates two synthetic fusion promoters, Pikali and Nocchu, for enhanced and balanced transgene expression in both rods and cones of retinal organoids.

The paper compares CRISPR/Cas9 gene editing efficiency in retinal organoids, HEK293T cells, and mouse models, finding retinal organoids better mirror in vivo editing outcomes.

This study shows that human photoreceptor cells transplanted into human retina organoids integrate structurally, forming clusters with cone and rod photoreceptors and host cell contacts.

This paper demonstrates that transplanted human photoreceptors from iPSC retinal organoids extensively incorporate into a murine cone degeneration model, leading to improved maturation, polarisation, and functional integration.

This study shows human brain organoids can form bilateral optic vesicles with cellular diversity and functionality, including light-responsive photoreceptors and neuronal networks.