Karen Tessmer

Transplanted human photoreceptors differentially survive, incorporate, and mature in mildly and severely degenerated mouse retinae

This study shows that transplanted human photoreceptors integrate and mature better in mildly degenerated retinas than severely degenerated ones, depending on the retinal microenvironment.

Extensive monolayer formation after transplantation depends on a RPE subpopulation derived from human iPSCs

The paper shows that passage 1 human iPSC-derived RPE cells form more extensive monolayers after transplantation compared to passage 2 cells, highlighting a subpopulation with higher transplantation potential.

Extensive incorporation, polarisation and improved maturation of transplanted human cones in a murine cone degeneration model

This paper demonstrates that transplanted human photoreceptors from iPSC retinal organoids extensively incorporate into a murine cone degeneration model, leading to improved maturation, polarisation, and functional integration.