Lois S. Weisman

This study identifies a stress-lipid kinase axis in NEPC driven by PIKfyve, revealing a synthetic vulnerability between PIKfyve and FASN that can be exploited for therapeutic targeting.

The paper shows that cargo adaptors bind myosin V through multiple sites, using a handhold mechanism to enhance motor-cargo interactions and regulation.

This study identifies PIKfyve as a targetable vulnerability in pancreatic cancer by showing its role in lipid metabolism and synthetic lethality with KRAS-MAPK inhibitors.

The paper shows that Pho85, a non-canonical CDK, initiates a pathway to restart the cell cycle after stress by phosphorylating Sch9 and Whi5, enabling cell survival.

This study identifies MTMR5 as a neuron-specific autophagy suppressor, showing its role in limiting autophagy and its potential as a therapeutic target for neurodegenerative diseases.