Vivette Denise D’Agati

This study identifies Fosl2 as a regulator of PEC-to-myofibroblast transition in kidney disease using mouse models and human biopsies.

This study shows WDFY3 protects against autoimmunity by enhancing macrophage efferocytosis, reducing autoantigen release, and suppressing T cell and inflammasome activation.

The paper defines the chromatin landscape of healthy and injured kidney cells using multi-omics data, identifying regulatory elements and transcription factor networks involved in injury response.

The paper shows the APOL1 p.N264K variant reduces the risk of FSGS and kidney disease in individuals with G2 APOL1 risk alleles.

The paper creates a high-resolution cellular atlas of healthy and injured kidney cell states and niches using single-cell and spatial technologies, identifying molecular signatures and pathways related to kidney injury.